33 articles - From Friday Mar 31 2023 to Friday Apr 07 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Clin Nutr |
meta-analyses and systematic reviews
| Am J Clin Nutr |
Dietary interventions for perinatal depression and anxiety: a systematic review and meta-analysis of randomized controlled trials. Despite their widespread popularity, PUFAs and elemental metals do not appear to effectively reduce perinatal depression. Vitamin D taken in doses of 1800 to 3500 International Units (IU) per day may have some promise. Additional high-quality, large-scale randomized controlled trials (RCTs) are needed to determine the true effectiveness of dietary interventions on perinatal depression and/or anxiety. Prospero registration date and number July 5 th 2020, CRD42020208830. |
| Inflamm Bowel Dis |
Endoscopic and Histological Placebo Rates in Crohn's Disease Clinical Trials: A Systematic Review and Meta-analysis. Endoscopic placebo rates vary according to trial phase and prior biologic exposure. These contemporary data will serve to inform CD trial design, sample size calculation, and end point selection for future trials. |
| Liver Transpl |
Definition and measurement of alcohol-related insight in early liver transplantation for acute alcohol-associated hepatitis: a systematic review. This systematic review reveals that ARI is a poorly defined construct which is not measured in a standardized way. Yet it is a commonly cited parameter in articles which describe the psychosocial evaluation and decision making of patients undergoing eLT for AAH. This article also discusses general challenges of assessing ARI during eLT for AAH, existing ARI definitions and rating scales, how ARI has been used to date in the broader hepatology and LT literature, and future areas for clinical and research progress. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
A randomized, controlled trial of a Nordic, protein-reduced complementary diet in infants: effects on body composition, growth, biomarkers and dietary intake at 12 and 18 months. Introduction of a predominantly plant-based, protein-reduced diet as part of complementary feeding is feasible and can increase fruit and vegetable intake. Clinical trial registry OTIS; ClinicalTrials.gov registration number NCT02634749. |
Effect of intra-trial mean 25(OH)D level on diabetes risk, by race and weight: an ancillary analysis in the D2d randomized study cohort. Among people with prediabetes, particularly for Black and White race groups and those with BMI <40 kg/m 2 , the optimal 25(OH)D level may be = 40 ng/mL to optimize diabetes prevention efforts. Trial identifier D2d ClinicalTrials.gov number, NCT01942694 |
Flavonoid intake and survival after diagnosis of colorectal cancer: A prospective study in two US cohorts. Higher intake of flavan-3-ol after CRC diagnosis was associated with lower CRC-specific mortality. Small, readily achievable increases in the intake of flavan-3-ol- rich foods, such as tea, may help improve survival in CRC patients. |
Higher adherence to the EAT-Lancet reference diet is associated with higher nutrient adequacy in the NutriNet-Santé cohort : a cross-sectional study. In the French context, although issues with the intake of certain nutrients may occur, a diet that remains within the planetary limits as the EAT-Lancet reference diet allows a favorable nutritional quality. |
Selecting a dietary supplement with appropriate dosing for 6 key nutrients in pregnancy. Almost no US dietary supplements provide key nutrients in the doses needed for pregnant women. Affordable and convenient products that fill the gap between food-based intake and estimated requirements of pregnancy without inducing excess intake are needed to support pregnant women and their offspring. Am J Clin Nutr 20XX; xx xx-xx. |
The association of macronutrient quality and its interactions with energy intake with survival among patients with ovarian cancer: results from a prospective cohort study. Intake of high-quality macronutrients before diagnosis was associated with improved survival among females with OC, especially for those with energy imbalance. |
| Inflamm Bowel Dis |
Novel Findings of Early Cardiac Dysfunction in Patients With Childhood-Onset Inflammatory Bowel Disease Using Layer-Specific Strain Analysis. Children and young adults with childhood-onset IBD displayed decreased midmyocardial deformation. Layer-specific strain could also be useful to identify indicators of cardiac dysfunction in patients with IBD. |
| J Crohns Colitis |
"Correlation of ultrasound scores with endoscopic activity in Crohn's disease: a prospective exploratory study". All IUS scores provided solid correlation with endoscopy and clinical symptoms. IBUS-SAS outperformed the others due to a more granular description that might particularly help in stratifying different levels of disease activity. Therefore, the use of IBUS-SAS in Centres with well-founded expertise in IUS may be suggested. |
Inflammatory Bowel Disease and Risk of Colorectal Polyps: A nationwide population-based cohort study from Sweden. In this nationwide population-based study, there was an increased risk of neoplastic colorectal polyps in IBD patients. Colonoscopic surveillance in IBD appears important, especially in UC and after 10 years of disease. |
Reduced serological response to COVID-19 booster vaccine is associated with reduced B cell memory in patients with Inflammatory Bowel Disease; VARIATION (VAriability in Response in IBD AgainsT SARS-COV-2 ImmunisatiON). Patients with IBD have an attenuated response to three doses of SARS-CoV-2 vaccine. Physicians should consider patients with higher anti-TNF drug levels and/or zinc deficiency as potentially at higher risk of attenuated response to vaccination. |
Spermidine ameliorates colitis via induction of anti-inflammatory macrophages and prevention of intestinal dysbiosis. Spermidine reduces intestinal inflammation by promoting anti-inflammatory macrophages, maintaining a healthy microbiome, and preserving epithelial barrier integrity in a PTPN2-dependent manner. |
Transepithelial barrier dysfunction drives microbiota dysbiosis to initiate epithelial clock-driven inflammation. In summary, the data demonstrate that barrier dysfunction induces dysbiosis and expansion of invasive microbes that lead to circadian disruption and mucosal inflammation. These results suggest that barrier-protective or bacterium-targeted precision medicine approaches may be of benefit to IBD patients. |
| Liver Transpl |
Early paracentesis is associated with better prognosis compared to late or no-paracentesis in hospitalized veterans with cirrhosis and ascites. Nationally, only 14.3% of admitted Veterans with cirrhosis and ascites received the AASLD guideline recommended diagnostic paracentesis within 24 hours of admission. Failure to complete early paracentesis was associated with higher odds of AKI, ICU transfer, and inpatient mortality. Universal and site-specific barriers to this quality metric should be evaluated and addressed to improve patient outcomes. |
Fluorescence confocal microscopy on liver specimens for full digitization of transplant pathology. Strength of agreement between frozen sections and FCM was superior to the comparison of conventional HE and FCM imaging. We introduce FCM as a potential alternative to frozen section that may represent a novel approach to liver transplant pathology where timely feedback is crucial, and the deployment of human resources is becoming increasingly difficult. |
Immature and activated phenotype of blood NK is associated with acute rejection in adult liver transplant. The blood-circulating NK-cell subset composition was consistent during AR, while the expressions of NKp30 and NKp46 were augmented. Collectively, a more immature CD56brightCD16- subset composition and an activated phenotype of high NKp30 expression were the general properties of blood-circulating NK cells in rejected LTx recipients, and the NKp30 positive ratio in CD56dimCD16+ NK subset pre-LTx possessed AR predictive potential. |
Multicenter evaluation of the Quantra with the QStat cartridge in adult patients undergoing liver transplantation. The results indicate that the Quantra with the QStat Cartridge provides comparable information as the ROTEM delta in the assessment of hemostatic function during liver transplant. The Quantra's simplicity of use and availability of rapid results may provide clinicians with a faster, more convenient means to assess coagulation and fibrinolysis status in the operating room and critical care setting. |
| Pancreatology |
Incidence and factors associated with portal vein thrombosis in patients with acute pancreatitis: A United States national retrospective study. This study demonstrated a significant association between PVT and factors such as pancreatic pseudocyst, bacteremia, and ileus in patients with AP. |
Pancreatic duct epithelial malignancy suggested by large focal pancreatic parenchymal atrophy in cystic diseases of the pancreas. Positive results on SPACE were significantly associated with the clinical diagnosis of IPMN and the large FPPA. Moreover, these disorders are significantly related. Surgery owing to positive results could lead to the histopathological diagnosis of HGP/CIS. |
Pancreatic exocrine insufficiency is a risk factor for kidney stones in patients with chronic pancreatitis. PEI and increase in BMI are risk factors for kidney stone development in patients with CP. Male CP patents are particularly at increased risk of nephrolithiasis. This should be taken into consideration in general clinical approach to raise awareness among patients and medical workers. |
Pre-emptive resection for intraductal papillary mucinous neoplasia - Long-term outcome is similar between non-invasive and early invasive lesions in a tertiary single center. Two thirds of the specimen from pre-emptive resections were of LGD and did not involve superior OS than in situ or early cancer. Due to high complication burden, efforts should be made to avoid resection when LGD is probable and rather identify more accurate predictors for surgery. |
Plenty of the editorials are available as full text through the publisher website using the provided link
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Clin Nutr |
| Inflamm Bowel Dis |
| Liver Transpl |
Letters to the editors and authors’ replies